Next Generation Sequencing (NGS) Market Assessment

Next Generation Sequencing (NGS) Market Assessment


Author: Stephane Budel

Date: September 26, 2019

Pages: 118 pages

Price: $5500

  • Abstract

    Next Generation Sequencing (NGS)* has transformed the life sciences and diagnostics landscapes. This technology is used for applications including human whole genome sequencing (WGS), whole exome sequencing (WES; 1-2% of the genome that encodes proteins), targeted sequencing using panels of a few-to-thousands of genes, and expression profiling (i.e., RNA-Seq). We forecast that the manufacturer market size will reach ~$4.4B in 2019, and grow at 14% p.a. to $6.5B in 2022, driven primarily by adoption from clinical customers worldwide**. NGS is poised to revolutionize not only medical research in academic laboratories and Biopharma, but also the health care landscape and applied markets (e.g., AgBio, food testing).

  • Select NGS Companies

  • Market Drivers, Moderators, and Trends


    • Accelerating adoption in clinical settings (both in clinical trial and routine testing) now representing about ½ half of the market, especially for clinical oncology across the patient journey from early (asymptomatic) detection (in trial stages at GRAIL, Freenome, etc) to therapy selection (e.g., Guardant Health, Foundation Medicine), or therapy monitoring and cancer recurrence testing (e.g., Natera)
    • Increased reagent usage on an expanding instrument installed base, across applications, and especially for higher throughput instruments (i.e., NovaSeq)
    • Increased adoption of the technology by new customers (e.g., Applied markets such as AgBio, Biopharma for patient stratification during clinical trials)
    • Increased usage for new scientific applications built upon sequencing detection (e.g., [single cell] RNA-Seq, ChIP-Seq, methylation studies, spatial profiling on NanoString GeoMx)


    • Excess capacity: previously installed instruments operating at 10-30% of capacity
    • Pricing pressure has decreased cost per Gb moderating overall revenue growth, due to competitive pressure (particularly from MGI), and the availability of more affordable instrument options (e.g., Illumina’s iSeq, Oxford Nanopore’s Flongle)
    • Reimbursement uncertainty and pushback in clinical settings (due in part to lack of education even in some cases where tests are covered by insurance companies) limiting access to the vast majority of clinical samples in the U.S.
    • Out-of-pocket pay for some tests (60-80%) in China limiting adoption
    • Continued bioinformatics and data analysis challenges, especially for structural variants or translational and clinical applications (e.g., clinical variant interpretation), gating access to most potentially addressable samples
    • Low growth in research funding in established markets

    Other Trends

    • Increased use of native long read technologies, most notably Oxford Nanopore
    • Increased number (and scale) of population sequencing programs (e.g., Korea planning to sequence 1M genomes by 2029)
    • Diversification of sequencing options driven by the launch of multiple new platforms by new players (e.g., BGI’s T7, Oxford Nanopore’s PromethION, Genapsys GENIUS), and many additional companies with novel sequencers
    • Consolidation of applications on increasingly differentiated platforms, based on their workflow, turnaround time and cost (e.g., human WGS on NovaSeq, field-based pathogen sequencing on the MinION)
    • Simplification of the overall workflow, with the launch of more automated instruments (e.g., S5) or automated sample preparation instruments (e.g., Ion Chef, NeoPrep, VolTRAX), saving time, and increasing reproducibility
    • Continued decentralization of sequencing runs driven by the availability of low cost desktop sequencers (e.g., MiSeq), but in turn a centralization of sequencing volumes as high throughput platforms can cost-effectively run 10,000’s of samples
    • Increasing use of service providers offering an alternative to in-house platform adoption, as many customers don’t have the budget for or interest in large capital expenditures for such fast-evolving technologies
    • Increasing number of players participating in this fast growing market, typically offering front end (sample preparation) or backend (bioinformatics) solutions, with most targeting (clinical) oncology
    • Increasing competitive intensity on dimensions others than cost per base pair (e.g., workflow, portability, clinical content)
  • Market Segmentations


    Companies that offer NGS products:
    • Illumina
    • Roche (Kapa Bio, Genia)
    • Thermo Fisher (Ion Torrent)
    • Pacific Biosciences
    • Oxford Nanopore
    • Qiagen
    • Others

    Product Type

    Type of product that manufacturer sells to its customers
    • Instruments (inc. software)
    • Reagents (inc. consumables)


    Buyers of NGS instruments, reagents, and consumables from manufacturers

    • Academia
    • Population Studies
    • Biopharma
    • Clinical
    • Applied Markets
    • Others


    Country / region of the world
    • U.S.
    • Europe
    • China
    • Asia Pacific (APAC)
    • Rest-of-the-world (ROW)


    Key scientific research question being investigated
    • Human WGS
    • WES
    • Targeted Resequencing
    • RNA-seq
    • Others

    Therapeutic Area

    Research focus including broad non-disease specific biological area as well as specific disease areas
    • Genomics
    • Oncology
    • Infectious Diseases
    • Method Development
    • Others